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                                        Gold developers are better than silver, for many applications.

                                        • Slow enhancement for an easy control of particle size
                                        • Better for SEM: Gold gives a much better backscatter signal than silver
                                        • Low background - No autonucleation for 40 minutes
                                        • Neutral pH for best ultrastructural preservation
                                        • Permanent staining: does not fade
                                        • Safe to use before osmium tetroxide etching --silver would dissolve.
                                        • Compatible with physiological buffers and other halide solutions
                                          --silver would precipitate.
                                        • Can be used for specimens on metal surfaces (e.g. cell culture substrates)
                                        • Light insensitive, Low viscosity, Mix-and-use
                                        • Our new favorite for EM!
                                        AuroVist™ 15 nmNew
                                        Gold X-ray Contrast Agent
                                        • Highest contrast of any blood pool contrast agent
                                        • Longest blood half-life
                                          of any x-ray contrast agent - 24 hours!
                                        Unparalleled for Micro CT!

                                        NewNi-NTA-Nanogold structural diagram5nm Ni-NTA-Nanogold®

                                        This simple, one-step kit adds His-tags to your recombinant proteins (or any particle), along with tightly bonded (but removable) Nanogold®-- at 5nm, you can take your sample straight to imaging under EM --with no silver or gold enhancement necessary. Also great under LM, and with columns and blots.

                                        Choose your solubility

                                        Functionalized Gold Nanoparticles

                                        Take your choice of solubility properties-- amphilic for all applications, hydrophilic for dissolving in water or alcohol, and hydrophobic for organic solvents like toluene.

                                        Gold Nanomaterials: Functionalized Gold Nanoparticles

                                        EnzMet™ -Enzyme Metallography for ultra-sensitive detection

                                        EnzMet™ (Enzyme Metallography) is a new biological labeling and staining method developed at Nanoprobes, which uses a targeted enzymatic probe with a novel metallographic substrate to provide a quantum leap in staining clarity over conventional chromogenic and fluorescent substrates for immunohistochemistry (IHC) and in situ hybridization (ISH) applications. It has proven highly sensitive both for ISH, where it readily visualizes endogenous copies of single genes, and immunohistochemistry (IHC) detection. It has also been used as an electrical detection method for biochips.

                                        GoldiBlot™ -Western blots for Ni-NTA His-tag detection

                                        Goldiblot™ His Detection Kit is a rapid, sensitive alternative to enzymatic methods for the detection of recombinant His-tagged proteins on membrane blots such as immunoblots and westerns. It uses nitrilotriacetic acid (NTA)-nickel (II)-functionalized gold nanoparticles, which bind tightly and selectively to His tags, followed by metal enhancement for direct visualization.


                                        Nanoprobes Product Lines

                                         


                                        Nanoprobes Products


                                        Conjugates with 1.4 nm Nanogold®

                                         

                                        Antibody conjugates (Fab' and IgG)

                                            Item # Product   Instructions PDF MSDS
                                            2001-2055 Purchase1.4 nm Nanogold® -antibody conjugates   1.4 nm Nanogold® -antibody conjugates:
                                        Instructions and Protocols
                                        [2001-PDF] MSDS
                                                       
                                         

                                        FluoroNanogold™ fluorescent conjugates

                                        PurchaseAlexa Fluor®* 647 - FluoroNanogold™ [ Product Page ]
                                            Item # Product   Instructions   MSDS
                                            7501 Alexa Fluor? 647 - FluoroNanogold?goat anti mouse IgG (H+L)   [2020-PDF] Instructions and Protocols MSDS
                                            7502 Alexa Fluor?647 - FluoroNanogold?Fab' fragment of goat anti mouse IgG (H+L)   [2020-PDF] Instructions and Protocols MSDS
                                            7503 Alexa Fluor?647 - FluoroNanogold?goat anti rabbit IgG (H+L)   [2020-PDF] Instructions and Protocols MSDS
                                            7504 Alexa Fluor?647 - FluoroNanogold?Fab' fragment of goat anti rabbit IgG (H+L)   [2020-PDF] Instructions and Protocols MSDS
                                            7505 Alexa Fluor?647 - FluoroNanogold?rabbit anti goat IgG (H+L)   [2020-PDF] Instructions and Protocols MSDS
                                            7506 Alexa Fluor?647 - FluoroNanogold?Fab' fragment of rabbit anti goat IgG (H+L)   [2020-PDF] Instructions and Protocols MSDS
                                            7507 Alexa Fluor?647 - FluoroNanogold?goat anti rat IgG (H+L)   [2020-PDF] Instructions and Protocols MSDS
                                            7508 Alexa Fluor?647 - FluoroNanogold?Fab' fragment of goat anti rat IgG (H+L)   [2020-PDF] Instructions and Protocols MSDS
                                            7552 Alexa Fluor?647 - FluoroNanogold?goat anti human IgG (H+L)   [2020-PDF] Instructions and Protocols MSDS
                                            7554 Alexa Fluor?647 - FluoroNanogold?goat anti Guinea Pig IgG (H+L)   [2020-PDF] Instructions and Protocols MSDS
                                            7516 Alexa Fluor?647 - FluoroNanogold?streptavidin   Instructions and Protocols [2020A-PDF] MSDS
                                        Alexa Fluor®* 488 - FluoroNanogold™
                                            7202-7255 PurchaseAlexa Fluor® 488 - FluoroNanogold™ -Fab' conjugates   Alexa Fluor® 488 - FluoroNanogold™ -Fab' conjugates:
                                        Instructions and Protocols
                                        [2020-PDF] MSDS
                                            7216 PurchaseAlexa Fluor® 488 - FluoroNanogold™ -Streptavidin   Alexa Fluor® 488 - FluoroNanogold™ -Streptavidin:
                                        Instructions and Protocols
                                        [2020A-PDF] MSDS
                                        Alexa Fluor®* 546 - FluoroNanogold™
                                            7402-7455 PurchaseAlexa Fluor® 546 - FluoroNanogold™ -Fab' conjugates   Alexa Fluor® 546 - FluoroNanogold™ -Fab' conjugates:
                                        Instructions and Protocols
                                        [2021-PDF] MSDS
                                            7416 PurchaseAlexa Fluor® 546 - FluoroNanogold™ -Streptavidin   Alexa Fluor®-546 FluoroNanogold™ -Streptavidin:
                                        Instructions and Protocols
                                        [2021A-PDF] MSDS
                                        Alexa Fluor®* 594 - FluoroNanogold™
                                            7302-7355 PurchaseAlexa Fluor®-594 FluoroNanogold™ -Fab' conjugates   Alexa Fluor®-594 FluoroNanogold™ -Fab' conjugates:
                                        Instructions and Protocols
                                        [2025-PDF] MSDS
                                            7316 PurchaseAlexa Fluor®-594 FluoroNanogold™ -Streptavidin   Alexa Fluor®-594 FluoroNanogold™ -Streptavidin:
                                        Instructions and Protocols
                                        [2025A-PDF] MSDS
                                        Fluorescein FluoroNanogold™
                                            7002-7055 PurchaseFluoroscein FluoroNanogold™ -Fab' conjugates   Fluoroscein FluoroNanogold™ -Fab' conjugates:
                                        Instructions and Protocols
                                        [2022-PDF] MSDS
                                            7016 PurchaseFluoroscein FluoroNanogold™ -Streptavidin   Fluoroscein FluoroNanogold™ -Streptavidin:
                                        Instructions and Protocols
                                        [2023-PDF] MSDS
                                                       
                                         

                                        Lipid Conjugates

                                            Item # Product   Instructions PDF MSDS
                                            4020 PurchasePalmitoyl 1.4 nm Nanogold®   Palmitoyl Nanogold®:
                                        Instructions and Protocols
                                        [4020-PDF] MSDS
                                           

                                        4021

                                        PurchaseDPPE 1.4 nm Nanogold®   DPPE-Nanogold®:
                                        Instructions and Protocols
                                        [4021-PDF] MSDS
                                            4022 PurchasePalmitoyl 0.8 nm Undecagold   Palmitoyl Undecagold:
                                        Instructions and Protocols
                                        [4022-PDF] MSDS
                                            4023 PurchaseDPPE 0.8 nm Undecagold   DPPE Undecagold:
                                        Instructions and Protocols
                                        [4023-PDF] MSDS
                                                       
                                         

                                        Streptavidin conjugates

                                            Item # Product   Instructions PDF MSDS
                                            2016 Purchase1.4 Nanogold® -Streptavidin   1.4 nm Nanogold® -Streptavidin:
                                        Instructions and Protocols
                                        [2016-PDF] MSDS
                                                       

                                        Enhancement / Developers

                                            Item # Product   Instructions PDF MSDS
                                            2012 PurchaseHQ Silver   HQ Silver:
                                        Instructions and Protocols
                                        [2012-PDF] MSDS
                                           

                                        2013

                                        PurchaseLI Silver   LI Silver:
                                        Instructions and Protocols
                                        [2013-PDF] MSDS
                                            2114 PurchaseGoldEnhance EM Plus   GoldEnhance EM Plus:
                                        Instructions and Protocols
                                        [2112-PDF] MSDS
                                            2113 PurchaseGoldEnhance EM   GoldEnhance EM:
                                        Instructions and Protocols
                                        [2113-PDF] MSDS
                                            2112 PurchaseGoldEnhance LM   GoldEnhance LM:
                                        Instructions and Protocols
                                        [2112-PDF] MSDS
                                            2115 PurchaseGoldEnhance Blots   GoldEnhance Blots:
                                        Instructions and Protocols
                                        [2112-PDF] MSDS
                                                       

                                        EnzMet™

                                            Item # Product   Instructions PDF MSDS
                                            6001 PurchaseEnzMet™ IHC / ISH HRP Detection Kit   EnzMet™ IHC / ISH HRP Detection Kit:
                                        Instructions and Protocols
                                        [6001-PDF] MSDS
                                           

                                        6002

                                        PurchaseEnzMet™ Western Blot HRP Detection Kit   EnzMet™ Western Blot HRP Detection Kit:
                                        Instructions and Protocols
                                        [6002-PDF] MSDS
                                            6010 PurchaseEnzMet™ for General Research Applications   EnzMet™ for General Research Applications:
                                        Instructions and Protocols
                                        [6010-PDF] MSDS
                                                       

                                        Gold Nanomaterials - Functionalized Gold NanoparticlesNew

                                        Amphilic Gold Nanoparticles
                                            Item # Product   Instructions PDF MSDS
                                            3012

                                        Purchase1-Mercapto-(triethylene glycol) methyl ether functionalized gold nanoparticles

                                         

                                        1-Mercapto-(triethylene glycol) methyl ether functionalized gold nanoparticles:
                                        Instructions and Protocols

                                        MSDS
                                        Hydrophilic Gold Nanoparticles
                                            Item # Product   Instructions PDF MSDS
                                            3013 Purchase(1-Mercaptoundec-11-yl) tetraethyleneglycol
                                        functionalized gold nanoparticles
                                          (1-Mercaptoundec-11-yl) tetraethyleneglycol functionalized gold nanoparticles:
                                        Instructions and Protocols
                                        MSDS
                                        Hydrophobic Gold Nanoparticles
                                            Item # Product   Instructions PDF MSDS
                                            3014 PurchaseDodecanethiol
                                        functionalized gold nanoparticles
                                          Dodecanethiol functionalized gold nanoparticles:
                                        Instructions and Protocols
                                        MSDS
                                            3015 PurchaseOctanethiol
                                        functionalized gold nanoparticles
                                          Octanethiol functionalized gold nanoparticles:
                                        Instructions and Protocols
                                        MSDS
                                                       

                                        Histadine (His-) tag labeling: Recombinant Protein Detection

                                        GoldiBlot™
                                            Item # Product   Instructions PDF MSDS
                                            2090
                                        2090A
                                        PurchaseGoldiBlot™   GoldiBlot™:
                                        Instructions and Protocols
                                        [2090-PDF] MSDS
                                        Ni-NTA-Nanogold®New
                                            Item # Product   Instructions PDF MSDS
                                            2080 Purchase1.8 nm Ni-NTA-Nanogold®   1.8 nm Ni-NTA-Nanogold®:
                                        Instructions and Protocols
                                        [2080-PDF] MSDS
                                            2082 Purchase5 nm Ni-NTA-Nanogold®   5 nm Ni-NTA-Nanogold®:
                                        Instructions and Protocols
                                        [2082-PDF] MSDS
                                            2084 Purchase10 nm Ni-NTA-Nanogold®   10 nm Ni-NTA-Nanogold®:
                                        Instructions and Protocols
                                        [2084-PDF] MSDS
                                                       

                                        FerroMag™ Magnetic Nanoparticles

                                            Item # Product   Instructions PDF MSDS
                                            9010 PurchaseMagnetic Nanoparticles - Fe3O4 (magnetite)   Magnetic Nanoparticles - Fe3O4 (magnetite):
                                        Instructions and Protocols
                                        [9010-PDF] MSDS
                                                       

                                        Negative Stains

                                            Item # Product   Instructions PDF MSDS
                                            2011 PurchaseNanoVan®   NanoVan®:
                                        Instructions and Protocols
                                        [2011-PDF] MSDS
                                           

                                        2018

                                        PurchaseNano-W®   Nano-W®:
                                        Instructions and Protocols
                                        [2018-PDF] MSDS
                                                       

                                        Reagents - 1.4nm Nanogold®

                                        1.4nm Nanogold® Particles (non-functionalized)
                                            Item # Product   Instructions PDF MSDS
                                            2010 Purchase1.4nm Nanogold® (Particles, non-reactive)   1.4nm Nanogold® (Particles, non-reactive):
                                        Instructions and Protocols
                                        [2010-PDF] MSDS
                                        Charged 1.4nm Nanogold®
                                            Item # Product   Instructions PDF MSDS
                                            2022 PurchasePositively Charged 1.4nm Nanogold®   Positively Charged 1.4nm Nanogold®:
                                        Instructions and Protocols
                                        [2022-PDF] MSDS
                                            2023 PurchaseNegatively Charged 1.4nm Nanogold®   Negatively Charged 1.4nm Nanogold®:
                                        Instructions and Protocols
                                        [2023-PDF] MSDS
                                        Monomaleimido 1.4nm Nanogold®
                                            Item # Product   Instructions PDF MSDS
                                            2020 PurchaseMonomaleimido 1.4nm Nanogold® (30 nmol)   Monomaleimido 1.4nm Nanogold® (30 nmol):
                                        Instructions and Protocols
                                        [2020-PDF] MSDS
                                            2020A PurchaseMonomaleimido 1.4nm Nanogold®
                                        (30 nmol in 5 aliquots)
                                          Monomaleimido 1.4nm Nanogold®
                                        (30 nmol in 5 aliquots):
                                        Instructions and Protocols
                                        [2020A-PDF] MSDS
                                            2020S PurchaseMonomaleimido 1.4nm Nanogold® (6 nmol)   Monomaleimido 1.4nm Nanogold® (6 nmol):
                                        Instructions and Protocols
                                        [2020S-PDF] MSDS
                                        Monoamino 1.4nm Nanogold®
                                            Item # Product   Instructions PDF MSDS
                                            2021 PurchaseMonoamino 1.4nm Nanogold® (30nmol)   Monoamino 1.4nm Nanogold® (30 nmol):
                                        Instructions and Protocols
                                        [2021-PDF] MSDS
                                            2021A PurchaseMonoamino 1.4nm Nanogold®
                                        (30nmol in 5 aliquots)
                                          Monoamino 1.4nm Nanogold®
                                        (30 nmol in 5 aliquots):
                                        Instructions and Protocols
                                        [2021A-PDF] MSDS
                                            2021S PurchaseMonoamino 1.4nm Nanogold® (6nmol)   Monoamino 1.4nm Nanogold® (6nmol):
                                        Instructions and Protocols
                                        [2021S-PDF] MSDS
                                        Mono-Sulfo-NHS-Nanogold® 1.4nm
                                            Item # Product   Instructions PDF MSDS
                                            2025

                                        PurchaseMono-Sulfo-NHS-Nanogold® 1.4nm (30 nmol)

                                         

                                        Mono-Sulfo-NHS-Nanogold® 1.4nm (30 nmol):
                                        Instructions and Protocols

                                        [2025-PDF] MSDS
                                            2025A PurchaseMono-Sulfo-NHS-Nanogold® 1.4nm
                                        (30 nmol in 5 aliquots)
                                          Mono-Sulfo-NHS-Nanogold® 1.4nm
                                        (30 nmol in 5 aliquots):
                                        Instructions and Protocols
                                        [2025A-PDF] MSDS
                                            2025S PurchaseMono-Sulfo-NHS-Nanogold® 1.4nm (6 nmol)   Mono-Sulfo-NHS-Nanogold® 1.4nm (6 nmol):
                                        Instructions and Protocols
                                        [2025S-PDF] MSDS
                                                       

                                        Reagents - UndecaGold (0.8nm Nanogold®)

                                        0.8nm UndecaGold Particles (non-functionalized)
                                            Item # Product   Instructions PDF MSDS
                                            2060 PurchaseUndecaGold (Particles, non-reactive)   UndecaGold (Particles, non-reactive):
                                        Instructions and Protocols
                                        [2060-PDF] MSDS
                                        Charged 0.8nm UndecaGold
                                            Item # Product   Instructions PDF MSDS
                                            2043 PurchasePositively Charged UndecaGold   Positively Charged UndecaGold:
                                        Instructions and Protocols
                                        [2043-PDF] MSDS
                                            2044 PurchaseNegatively Charged UndecaGold   Negatively Charged UndecaGold:
                                        Instructions and Protocols
                                        [2044-PDF] MSDS
                                        Monomaleimido 0.8nm UndecaGold
                                            Item # Product   Instructions PDF MSDS
                                            2030 PurchaseMonomaleimido UndecaGold   Monomaleimido UndecaGold:
                                        Instructions and Protocols
                                        [2030-PDF] MSDS
                                            2030A PurchaseMonomaleimido UndecaGold (5 aliquots)   Monomaleimido UndecaGold (5 aliquots):
                                        Instructions and Protocols
                                        [2030A-PDF] MSDS
                                            2030S PurchaseMonomaleimido UndecaGold (10 nmol)   Monomaleimido UndecaGold (10 nmol):
                                        Instructions and Protocols
                                        [2030S-PDF] MSDS
                                        Monoamino 0.8nm UndecaGold
                                            Item # Product   Instructions PDF MSDS
                                            2031 PurchaseMonoamino UndecaGold   Monoamino UndecaGold:
                                        Instructions and Protocols
                                        [2031-PDF] MSDS
                                            2031A PurchaseMonoamino UndecaGold (5 aliquots)   Monoamino UndecaGold (5 aliquots):
                                        Instructions and Protocols
                                        [2031A-PDF] MSDS
                                            2031S PurchaseMonoamino UndecaGold (10nmol)   Monoamino UndecaGold (10nmol):
                                        Instructions and Protocols
                                        [2031S-PDF] MSDS
                                        Mono-Sulfo-NHS-UndecaGold 0.8nm
                                            Item # Product   Instructions PDF MSDS
                                            2045

                                        PurchaseMono-Sulfo-NHS-UndecaGold

                                         

                                        Mono-Sulfo-NHS-UndecaGold:
                                        Instructions and Protocols

                                        [2045-PDF] MSDS
                                            2045A PurchaseMono-Sulfo-NHS-UndecaGold (5 aliquots)   Mono-Sulfo-NHS-UndecaGold (5 aliquots):
                                        Instructions and Protocols
                                        [2045A-PDF] MSDS
                                            2045S PurchaseMono-Sulfo-NHS-UndecaGold (10 nmol)   Mono-Sulfo-NHS-UndecaGold (10 nmol):
                                        Instructions and Protocols
                                        [2045S-PDF] MSDS
                                                       
                                        X-ray Contrast Agents

                                        X-ray Contrast Agents: AuroVist™New

                                            Item # Product   Instructions PDF MSDS
                                            1115 PurchaseAuroVist™-15 nm   AuroVist™-15 nm:
                                        Instructions and Protocols
                                        [1102-PDF] MSDS
                                            1115A PurchaseAuroVist™-15 nm, 5 vial package   AuroVist™-15 nm, 5 vial package:
                                        Instructions and Protocols
                                        [1102-PDF] MSDS
                                            1102 PurchaseAuroVist™-1.9 nm   AuroVist™-1.9 nm:
                                        Instructions and Protocols
                                        [1102-PDF] MSDS
                                            1102A PurchaseAuroVist™-1.9 nm, 5 vial package   AuroVist™-1.9 nm, 5 vial package:
                                        Instructions and Protocols
                                        [1102A-PDF] MSDS

                                        EnzMet™

                                            Item # Product   Instructions PDF MSDS
                                            6001 PurchaseEnzMet™ IHC / ISH HRP Detection Kit   EnzMet™ IHC / ISH HRP Detection Kit:
                                        Instructions and Protocols
                                        [6001-PDF] MSDS
                                           

                                        6002

                                        PurchaseEnzMet™ Western Blot HRP Detection Kit   EnzMet™ Western Blot HRP Detection Kit:
                                        Instructions and Protocols
                                        [6002-PDF] MSDS
                                            6010 PurchaseEnzMet™ for General Research Applications   EnzMet™ for General Research Applications:
                                        Instructions and Protocols
                                        [6010-PDF] MSDS
                                                       
                                                       
                                        Discontinued Products

                                        Colloidal Gold Conjugates [discontinued]

                                            Item # Product   Instructions PDF MSDS
                                            CG0300
                                        ...CG3054
                                        3, 5, 10, 15, 30 nm Colloidal Gold Conjugates   Colloidal Gold Conjugates:
                                        Instructions and Protocols
                                        MSDS
                                                       

                                        Conducting Polymers [discontinued]

                                            Item # Product   Instructions PDF MSDS
                                            3ODP 3-Octadecylpyrrole   3-Octadecylpyrrole:
                                        Instructions and Protocols
                                        [1102-PDF] MSDS
                                            3ODOP 3-Octadecanoylpyrrole   3-Octadecanoylpyrrole:
                                        Instructions and Protocols
                                        [1102A-PDF] MSDS
                                                       

                                        *Alexa Fluor is a registered trademark of Molecular Probes, Inc.

                                         

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